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Doxycycline Hyclate

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Description

Doxycycline hyclate is a semisynthetic tetracycline antibiotic effective against bacteria such as Mycoplasma pneumoniae and Haemophilus influenzae. It is also a broad-spectrum inhibitor of matrix metalloproteases (MMPs). Doxycycline hyclate is routinely used to select for cells containing the pcDNA3.1 resistance plasmid in cell line 293 at an effective concentration of 2 μg/mL. It is freely soluble in aqueous solution.

Tetracyclines are antibiotics made up of a four-ring system. They bind the 30s ribosomal subunit, preventing the aminoacyl-tRNA from attaching to the A site. Consequently, protein synthesis is inhibited.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Doxycycline Hyclate

MOLECULAR BIOLOGY GRADE

Formula: C22H24N2O8 ∙ HCl ∙ ½(H2O) ∙ ½(C2H6O)

MW: 512.94 g/mol

Storage/Handling: Store at 2-8°C.  Product is light sensitive. 

PubChem Chemical ID: 54686183

Catalog ID D-500
CAS # 24390-14-5
MW 512.94 g/mol
Grade MOLECULAR BIOLOGY GRADE
Storage/Handling Store at 4°C.
P Protocol
O Other
C Certificate of Analysis
S Safety Data Sheet

Additional information

CatalogID

D-500-1, D-500-10, D-500-100, D-500-25