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Pepstatin A

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Description

Pepstatin A is a competitive, reversible aspartic protease inhibitor and inhibits proteases such as pepsin, chymosin, renin, HIV proteases, and cathepsins D and E. Peptstatin A is highly selective and is often used in a mixture with other enzyme inhibitors. In vitro studies have shown pepstatin A is the only aspartic acid inhibitor that exhibits inhibitory effects on HIV proteases.

Pepstatin A is effective at inhibiting most affected proteases at a concentration of 1μM, but can inhibit pepsin at the picomolar range of concentrations. It is believed to function by way of a collected-substrate inhibition mechanism. Pepstatin A may also suppress differentiation of osteoclasts by inhibiting phosphorylation of MAP kinase and inhibiting NFATc1 expression.

Product Specifications

Pepstatin A

MOLECULAR BIOLOGY GRADE

Formula: C34H63N5O9

MW: 685.89 g/mol

PubChem Chemical ID:
5478883

Storage/Handling: Store at 4°C.

Pepstatin A is soluble in acetic acid, DMSO, ethanol, and methanol

Catalog ID P-020
CAS # 26305-03-3
MW 685.89 g/mol
Grade MOLECULAR BIOLOGY GRADE
P Protocol
O Other
C Certificate of Analysis
S Safety Data Sheet

Additional information

CatalogID

P-020-100, P-020-25, P-020-5