Description
Description | Hydroxy-PEG2-CH2COONa is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Synonyms | HO-PEG2-CH2COONa |
Molecular Weight |
187.147 |
Formula | C6H12NaO5 |
CAS No. | 42588-76-1 |
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year