Description
| Description | Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker. This compound is useful in the synthesis of PROTACs, as per reference [1]. |
| In vitro | Thalidomide-O-amido-C8-NH2, referred to as Compound DL7-TL, serves as a degron-linker within the PROTAC framework, covalently connecting to both a degron and a targeting ligand. This configuration enables the degron, a molecule that binds to ubiquitin ligases (e.g., cereblon), to guide the targeting ligand toward specific proteins[1], facilitating their ubiquitination and subsequent degradation. |
| Synonyms | E3 Ligase Ligand-Linker Conjugates 20, Cereblon Ligand-Linker Conjugates 2 |
| Molecular Weight |
458.51 |
| Formula | C23H30N4O6 |
| CAS No. | 1950635-15-0 |
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
