Description
| Description | 1-(2-fluoroethyl)-3-{4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl}urea is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively. |
| Targets&IC50 | PI3Kα:825nM, mTOR:0.7nM |
| In vitro | 1-(2-fluoroethyl)-3-{4-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)thieno[3,2-d]pyrimidin-2-yl]phenyl}urea inhibits the growth of LNCaP cell with IC50 of 87nM[1]. |
| Molecular Weight |
427.5 |
| Formula | C21H22FN5O2S |
| CAS No. | 1144075-36-4 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
( < 1 mg/ml refers to the product slightly soluble or insoluble )
