Description
| Description | 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-phenylurea is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively. |
| Targets&IC50 | PI3Kα:82nM, mTOR:1.25nM |
| In vitro | 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-phenylurea inhibits the growth of LNCaP cell with IC50 of 140nM[1]. |
| Molecular Weight |
457.55 |
| Formula | C25H23N5O2S |
| CAS No. | 1144075-42-2 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
( < 1 mg/ml refers to the product slightly soluble or insoluble )
