Description
AEBSF is an irreversible serine protease inhibitor. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin, kallikrein and thrombin. It inhibits the active site of the enzyme through acylation. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25mM. Aqueous solutions are stable between pH 5-6; limited stability above pH 7.5.
Attention Canadian and Mexican customers: This product is a hazardous and can only ship via Air.
Applications
- Serine Protease inhibitor
- SREBP protein activation
- PMSF/DFP alternative
Storage and Handling
Store at -20°C. Protect from light.
Working Concentration
Make stock solutions at 100mM. Aliquot and store at -20°C for up to 2 months.
AEBSF working concentrations are usually between 0.1-1.0mM and should be made daily.
