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(+)-Bicuculline

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Description

(+)-Bicuculline, a light-sensitive competitive GABAA and GABAA-gated chloride channel antagonist, functions in the biochemical field as a drug, CNS stimulator, convulsant and neurotransmitter. Its chemical identities are alkaloid and phthalide-isoquinoline compound. Extracted from plant alkaloid in 1932, this metabolite has been definitively located in Adlumia fungosa, Dicentra cucullaria, Fumariaceae and some species of Corydalis. (+)-Bicuculline acts primarily on ionotropic GABAA receptors but also blocks Ca2+-activated potassium channels and can act as an agrochemical.

As a poisonous neurotoxin, it affects nervous system responses associated with GABAA by binding to the receptors but not activating them, thus inhibiting the action of gamma-aminobutyric acid. This produces a powerful convulsive reaction mimicking epilepsy and has been used in lab studies of the condition. Administered with NMDA, it has induced paraplegia. Injection to the amygdala has also produced GABA-related anxiolytic effects on emotional states.

Product Specifications
(+)-Bicuculline
Bicuculline

Bicuculline+

Formula:
C20H17NO6

MW:
367.35 g/mol

Storage/Handling:
Store at 4°C.

PubChem Chemical ID:
10237

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Catalog ID B-040
CAS # 485-49-4
MW 367.35 g/mol
UN Number 1544
Item Class 6.1
Group Number II

Additional information

CatalogID

B-040-100, B-040-25