Description
| Description | Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR with IC50 of 1.3 nM. |
| Targets&IC50 | GlyR α1-A288Gβ:0.706 μM, GlyR α1-A288G:0.149 μM, GABAR:1.3 nM(S. litura RDL), GABAA α1β3γ2:3 μM(mammalian), GlyR:3 μM(human) |
| In vitro | Broflanilide is an insecticide and metabolized to desmethyl-broflanilide. Desmethyl-broflanilide shows weak activity against human GABAA α1β2γ2 receptor, the mammalian GABAA α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC50s >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G with IC50s of 0.706 and 0.149 μM respectively. |
| Molecular Weight |
663.28 |
| Formula | C25H14BrF11N2O2 |
| CAS No. | 1207727-04-5 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 225 mg/mL (339.22 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
