Description
| Description | Daptomycin (LY146032) is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA. |
| In vivo | Administering daptomycin at a dosage of 10 mg/kg twice daily significantly reduced the amount of organisms per kidney compared to infected untreated controls within 48 hours of treatment initiation. Although a 20 mg/kg dose administered once daily is less effective, it still significantly lowers colony counts after 4 days of therapy, with its efficacy being comparable to that of vancomycin or vancomycin-gentamicin administered twice daily[4]. |
| Synonyms | LY146032 |
| Molecular Weight |
1620.67 |
| Formula | C72H101N17O26 |
| CAS No. | 103060-53-3 |
Storage
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 32.4 mg/mL (20 mM)
DMSO: 45 mg/mL (27.77 mM)
