Description
| Description | Defactinib is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. |
| Kinase Assay | Cell-free Kinase Activity Assays: IC50 values for TG101348 are determined commercially using the InVitrogen kinase profiling service for a 223 kinase screen that included JAK2 and JAK2V617F or Carna Biosciences for the screen of all Janus kinase family members including JAK1 and Tyk2. ATP concentration is set to approximately the Km value for each kinase. |
| Cell Research | Ovarian cancer cells are treated with increasing concentrations of VS-6063 for 96 hours and then subjected to the MTT assay. Results are confirmed with triplicate experiments.(Only for Reference) |
| Synonyms | PF-04554878, VS-6063 |
| Molecular Weight |
510.49 |
| Formula | C20H21F3N8O3S |
| CAS No. | 1073154-85-4 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 50 mg/mL (97.94 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
