Description
| Description | Desipramine Hydrochloride a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically. |
| Targets&IC50 | NET:4 nM (Ki), DAT:78720 nM (Ki), SERT:61 nM (Ki) |
| Synonyms | JB-8181, EX-4355, Norimipramine, G-35020, NSC-114901, Desmethylimipramine |
| Molecular Weight |
302.84 |
| Formula | C18H23ClN2 |
| CAS No. | 58-28-6 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 55 mg/mL(181.6 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
