Description
| Description | Ensitrelvir (S-217622) is an orally active inhibitor of SARS-CoV-2 3CL protease with IC50 of 13 nM. |
| Targets&IC50 | 3CLpro (SARS CoV-2):13 nM |
| In vitro | The EC50 values for SARS-CoV and MERS-CoV were 0.21 and 1.4 μM respectively. In a cytopathic effect (cpe)-inhibition assay of SARS-CoV-2 infected VeroE6/TMPRSS2 cells, Ensitrelvir shows the EC50 values are approximately 0.4 μM for both wild-type virus and Alpha, Beta, Gamma and Delta variants[1]. |
| In vivo | Ensitrelvir inhibits intrapulmonary replication of SARS-CoV-2 in mice in a dose-dependent manner[1]. |
| Synonyms | S-217622 |
| Molecular Weight |
531.88 |
| Formula | C22H17ClF3N9O2 |
| CAS No. | 2647530-73-0 |
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 160 mg/mL (300.82 mM)
