Description
| Description | Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. |
| Targets&IC50 | ERα (mouse):2.3 nM, ERα (human):28 nM |
| In vitro | Estradiol benzoate is asynthetic ester, specifically the 3-benzoyl ester, of the natural estrogen, estradiol. Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position and is often used in combination with a progestin to induce estrus in domestic livestock. This compound binds to the human and murine estrogen receptor α (ERα), and chicken ER with IC50 values in the range of 22-28 nM. This reflects a 6-10 fold reduction in binding affinity compared to estradiol. [1] |
| Synonyms | Benzoestrofol, Benzhormovarine, Benovocylin |
| Molecular Weight |
376.49 |
| Formula | C25H28O3 |
| CAS No. | 50-50-0 |
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 18.33 mg/mL (48.7 mM),
Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
