Description
| Description | GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling. |
| In vitro | GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested[1]. |
| In vivo | GNF-6231 has favorable potency and a PK profile across preclinical species upon oral administration. The reference for orally in MMTV-Wnt1 tumor-bearing mice is dosed at 3 mg/kg. GNF-6231 showed very robust dose-related antitumor efficacy[1]. |
| Molecular Weight |
448.49 |
| Formula | C24H25FN6O2 |
| CAS No. | 1243245-18-2 |
Storage
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 36mg/mL (80.3mM)
