Description
| Description | ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM). |
| Targets&IC50 | KCNQ2/Q3:0.69 μM |
| In vitro | ICA-069673 is 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5. It has no inhibitory against a panel of cardiac ion channels (IC50> 30 μM for hERG, Nav1.5, L type channels, and KCNQ1). ICA-069673 (10 μM) has no activity on GABA(A) gated channels. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, a 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3. |
| Synonyms | ICA069673 |
| Molecular Weight |
269.63 |
| Formula | C11H6CLF2NO3 |
| CAS No. | 582323-16-8 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 34 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
