Description
| Description | Lipoxamycin hemisulfate is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity. |
| In vitro | Lipoxamycin hemisulfate shows antifungal activity against a panel of human pathogenic fungi with better potency against some of the Candida species (MIC = 0.25-16 µg/mL)[1]. |
| In vivo | In Chinese hamster ovary cell mutant, Lipoxamycin hemisulfate is highly toxic in mice when applied subeutaneously or topically[1]. |
| Synonyms | Lipoxamycin, sulfate (2:1), U26146D, U-26146D, U 26146D, Lipoxamycin |
| Molecular Weight |
843.08 |
| Formula | C38H74N4O14S |
| CAS No. | 11075-87-9 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 36mg/mL (42.7mM),
ultrasonic and warming and heat to 60°C
( < 1 mg/ml refers to the product slightly soluble or insoluble )
