Description
| Description | N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide is a potent and selective Enhancer of Zeste Homolog 2 (EZH2) inhibitor with IC50 0f 37.6 nM and 79.1 nM for EZH2 WT and EZH2-Y641F, respectively. |
| In vitro | N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide exhibits antiproliferative effects against the WSU-DLCL2 cell line with GI50 of 0.2 μM. |
| Molecular Weight |
542.67 |
| Formula | C32H38N4O4 |
| CAS No. | 2238820-26-1 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: <5.43 mg/mL (10 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
