Description
| Description | Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses. |
| In vitro | GSNO completely abolished the AngII-dependent AT1 receptor-mediated vasoconstriction of cerebral arteries. GSNO had no impact on responses to other vasoconstrictors sharing (phenylephrine, U46619) or not (5-HT) the same signalling pathway[1]. |
| In vivo | Elevated blood pressure, proteinuria, and intrauterine growth restriction associated with PE were induced in Sprague-Dawley rats using L-NAME. These were partially reversed with the use of GSNO[3]. |
| Synonyms | S-Nitrosoglutathione, SNOG, Glutathione thionitrite, GSNO |
| Molecular Weight |
336.32 |
| Formula | C10H16N4O7S |
| CAS No. | 57564-91-7 |
Storage
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: Soluble
H2O: 20 mg/ml(59.47 mM)
