Description
| Description | Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM. |
| Targets&IC50 | PDE4:2.0 μM, PDE4:3.1 μM(Ki) |
| In vivo | RO-20-1724 was found to not only improve learning and memory in MWM and PA paradigms but also restore STZ induced elevation in cholinesterase activity. Further, RO-20-1724 significantly reduced malondialdehyde and nitrite levels, and restored the glutathione levels indicating attenuation of oxidative stress[2]. |
| Synonyms | Ro-20-1724, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone, Ro20-1724 |
| Molecular Weight |
278.35 |
| Formula | C15H22N2O3 |
| CAS No. | 29925-17-5 |
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 50 mg/Ml(179.63 mM)
Ethanol: 50 mg/Ml(179.63 mM)
