Description
| Description | Seltorexant crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human and rat OX2R). |
| Targets&IC50 | OX2:8.0 (pki)(human), OX2:8.1 (pki)(rat) |
| In vivo | Seltorexant (3-30 mg/kg; p.o.) dose-dependently causes and prolongs sleep in male Sprague-Dawley rats. The sleep-promoting effects of Seltorexant (30 mg/kg; p.o.; per day for 7 days) are maintained upon 7-day repeated dosing in rats [1]. |
| Synonyms | JNJ-42847922 |
| Molecular Weight |
407.44 |
| Formula | C21H22FN7O |
| CAS No. | 1293281-49-8 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 250 mg/mL (613.59 mM),
Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
