Description
| Description | Splenopentin diacetate (Splenin pentapeptide (32-36)) is a synthetic immunomodulating peptide and can reproduce the biological activities of splenin and thymic hormone thymopoietin. |
| In vitro | Splenopentin diacetate (0.1 ng/mL-10 μg/mL) induces phenotypic differentiation of both T- and B-cell precursor cells, to increase the number of antibody-forming cells in mice after gamma irradiation[2]. |
| In vivo | Splenopentin diacetate (0.01-100 μg; i.p.) has no demonstrable effect on neuromuscular transmission of mice[2]. Splenopentin diacetate (1 mg/kg; i.p.) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone[3]. |
| Synonyms | Thymopoietin III pentapeptide (32-36), SP5, Splenopentin Acetate, Splenin pentapeptide (32-36), Arg-lys-glu-val-tyr |
| Molecular Weight |
753.84 |
| Formula | C33H55N9O11 |
| CAS No. | 105184-37-0 |
Storage
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: Insoluble
DMSO: Soluble
