Description
| Description | SRS11-92 is a ferroptosis inhibitor and a derivative of ferrostatin-1 |
| In vitro | SRS11-92 inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells (EC50 = 6 nM).?SRS11-92 (2 M) inhibits iron-induced cell death in isolated mouse kidney proximal tubules, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM. |
| In vivo | SRS11-92 increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington s disease in a concentration-dependent manner.?SRS11-92 (3 M) increases production of reactive oxygen species (ROS) in L. major promastigotes in a time-dependent manner.?It is selectively toxic to L. major promastigotes (LD50 = 3.34 M) over U2OS human osteoblasts, RAW 264.7 macrophages, and intraperitoneal macrophages when used at a concentration of 80 M. |
| Synonyms | AA9 |
| Molecular Weight |
352.47 |
| Formula | C22H28N2O2 |
| CAS No. | 1467047-25-1 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 10 mg/mL (28.37 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
