Description
| Description | Vancomycin Hydrochloride is the hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. |
| In vitro | Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide that is structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci[2]. |
| In vivo | Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects[1]. Vancomycin treatment of infected mice is related to improved clinical, diarrhea, and histopathology scores and survival during treatment[3]. |
| Synonyms | Vancomycin HCl |
| Molecular Weight |
1485.71 |
| Formula | C66H76Cl3N9O24 |
| CAS No. | 1404-93-9 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
H2O: 33.33 mg/mL (22.43 mM),
Need ultrasonic
DMSO: 24 mg/mL (16.15 mM),
Need ultrasonic and warming
( < 1 mg/ml refers to the product slightly soluble or insoluble )
