Description
| Description | YS-49 is an activator of PI3K/Akt (a downstream target of RhoA). |
| In vitro | In RAVSMC and RAW 264.7 cells, YS-49 (1-100?μM; 18 hours; ) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30?μM, respectively[2].At the transcriptional level, YS-49 (10-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells [2]. |
| In vivo | In male Sprague Dawley rats,YS-49 (5?mg/kg; intraperitoneal injection; 8 hours) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM[2]. |
| Molecular Weight |
386.28 |
| Formula | C20H20BrNO2 |
| CAS No. | 132836-42-1 |
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 10 mg/mL (25.89 mM）,
Sonication and heating to 60℃ are recommended.
DMSO: 100 mg/mL (258.88 mM)
