Description
| Description | Fmoc-Thr[GalNAc(Ac)3-α-D]-OH is a reagent for the preparation of a synthetic MUC1 Glycopeptide Bearing βGalNAc-Thr as a Tn antigen isomer which induces the antibody production against tumor cells. Fmoc-Thr[GalNAc(Ac)3-α-D]-OH is a starting material to make trimeric MUC1 immunodominant motif antigen-based anti-cancer vaccine candidates. |
| In vitro | The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn antigen)[1]. |
| Synonyms | Fmoc-Thr[GalNAc(Ac)3-α-D]-OH, Fmoc-Thr(Ac₃AcNH-α-Gal)-OH |
| Molecular Weight |
670.66 |
| Formula | C33H38N2O13 |
| CAS No. | 116783-35-8 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
H2O: soluble
( < 1 mg/ml refers to the product slightly soluble or insoluble )
