Description
| Description | ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter. |
| In vitro |
In PBMCs of viremic HIV-infected individuals,ZL0580 (8 μM, 2 days) induces HIV transcriptional suppression with low toxicity[1]. ZL0580 treatment (10 μM) suppresses both PMA-stimulated and basal HIV transcription[1]. |
| Molecular Weight |
532.53 |
| Formula | C25H23F3N4O4S |
| CAS No. | 2377151-10-3 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 250 mg/mL (469.46 mM),
Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
