Description
| Description | AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively). |
| Targets&IC50 | TRPV1 (rat):85.6 nM, TRPV1 (human):24.5 nM |
| In vivo | In a rat model of inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant, 30-100 mg/kg AMG 9810 reverses thermal and mechanical hyperalgesia[3]. |
| Molecular Weight |
337.41 |
| Formula | C21H23NO3 |
| CAS No. | 545395-94-6 |
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 33 mg/mL (97.80 mM)
