Description
| Description | Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation. |
| Targets&IC50 | IL6/STAT3 signaling pathway:11.56 μM (IC50) |
| In vitro | Angoline as a potent and selective inhibitor of the STAT3 signaling pathway (IC50=11.56 μM).?Angoline inhibited STAT3 phosphorylation and its target gene expression and consequently induced growth inhibition of human cancer cells with constitutively activated STAT3 (IC50=3.14-4.72 μM).?This work provided a novel lead for the development of anti-cancer agents targeting the STAT3 signaling pathway. |
| Synonyms | 6-Methoxyldihydrochelerythrine |
| Molecular Weight |
379.41 |
| Formula | C22H21NO5 |
| CAS No. | 21080-31-9 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 30 mg/ml (79.07 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
