Description
| Description | Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment. |
| In vitro | Bax inhibitor peptide V5 (BIP-V5; 0-50 μM) decreases cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells.[1]. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively[2]. |
| In vivo | Bax inhibitor peptide V5 (BIP-V5; 100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model[2]. |
| Synonyms | Bax inhibitor peptide V5 acetate（579492-81-2 free base) |
| Molecular Weight |
646.85 |
| Formula | C29H54N6O8S |
| CAS No. | T10463L |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
H2O: 100 mg/mL (170.42 mM),
Need ultrasonic
DMSO: 100 mg/mL (170.42 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
