Description
| Description | Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia. |
| In vitro | In healthy male rats, daily treatment with Dutasteride (100mg/kg) resulted in a prostate size that was half the size of that in control rats. |
| In vivo | Dutasteride effectively inhibits Type I 5AR (IC50=6 nM) and Type II 5AR (IC50=7 nM). In LNCaP cells (IC50=1 μM), it suppresses DHT-induced PSA secretion and proliferation, and competes for androgen receptor (AR) binding (IC50=1.5 μM). Additionally, dutasteride reduces cell viability and proliferation in both androgen-responsive (LNCaP) and androgen-nonresponsive (DU145) human prostate cancer (PCa) cell lines. |
| Synonyms | GG 745, Avodart, GI 198745 |
| Molecular Weight |
528.53 |
| Formula | C27H30F6N2O2 |
| CAS No. | 164656-23-9 |
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 6 mg/mL (11.35 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 58 mg/mL (109.7 mM)
