Description
| Description | Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM). |
| Targets&IC50 | BACE1:8.55 μM, BChE:6.03 µM, AChE:1.07 µM |
| In vitro | Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes (IC50: 52.8 μM). Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation [2]. Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner [3]. |
| In vivo | Body weight, food consumption, water intake, and urinary output of KK-Ay mice were reduced after being treated with Epiberberine (225 mg/kg, p.o. daily for 40 days). |
| Source |
| Synonyms | Epiberberine (chloride) |
| Molecular Weight |
371.8 |
| Formula | C20H18ClNO4 |
| CAS No. | 889665-86-5 |
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 7.4 mg/mL (19.9 mM)
