Description
| Description | Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM). |
| Targets&IC50 | Norepinephrine uptake:1.7 μM |
| In vitro | Hydroxybupropion shows stronger antitetrabenazine activity and has a lower LD50 value than the erythro- and threo- metabolites. Hydroxybupropion inhibits norepinephrine and dopamine uptake, antagonizes nicotine, and shows antidepressant effects in rodents[1]. |
| Synonyms | Hydroxybupropione, 6-Hydroxybupropion, Hydroxybupropion, (+/-)- |
| Molecular Weight |
255.74 |
| Formula | C13H18ClNO2 |
| CAS No. | 92264-81-8 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 90mg/mL (351.9mM),
Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
