Description
| Description | M1145 acetate, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 acetate shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 acetate has an additive effect on the signal transduction of galanin[1]. |
| In vitro | M1145 acetate has an additive effect on the signal transduction of galanin, are concentrations of M1145 acetate of 0.1 μM and higher all give a maximum transduction. Signal transduction was examined by assessing the ability to stimulate inositol phosphates (IP) production in CHO cells expressing GalR2. Treatment with M1145 acetate, which stimulates IP production with an EC50 of 38 nM[1]. |
| Molecular Weight |
2834.28 |
| Formula | C130H209N37O34 |
Storage
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
