Description
| Description | Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent. |
| In vitro | Mivotilate has a novel activation mode that tolerates mutation of histidine 285 to tyrosine[1]. Mivotilate is a nontoxic and potent activator of the aryl hydrocarbon receptor. Mivotilate causes cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor[3]. |
| In vivo | Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats. Mivotilate (75-300 mg/kg) rapidly decreases immunoreactive CYP2E1 protein. Mivotilate ( 150 mg/kg, p.o.) decreases CYP2E1-mediated NDMA demethylase activity in rats but displays no obvious effect on NADPH-dependent P450 oxidoreductase activity [2]. |
| Synonyms | YH439 |
| Molecular Weight |
330.45 |
| Formula | C12H14N2O3S3 |
| CAS No. | 130112-42-4 |
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
