Description
| Description | MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2. |
| Targets&IC50 | BRD4 BD1/2:18.4 nM (ki) |
| In vitro | MS645 blocks the proliferation of triple-negative breast cancer (TNBC) cells. MS645 down-regulates proinflammatory cytokines and genes for cell-cycle control and DNA damage repair that are largely unaffected by monovalent BRD inhibition[1]. |
| Molecular Weight |
938.04 |
| Formula | C48H54Cl2N10O2S2 |
| CAS No. | 2250091-96-2 |
Storage
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 180 mg/mL (191.9 mM),
Sonication is recommended.
