Description
| Description | Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis. |
| In vitro | Piperazine erastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable [1]. |
| In vivo | A significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group, in the xenograft mouse model. Ptgs2 is upregulated in mouse liver with piperazine erastin (10 or 60 mg/kg) administration[1]. |
| Molecular Weight |
645.19 |
| Formula | C35H41ClN6O4 |
| CAS No. | 1538593-71-3 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 33.33 mg/mL (51.66 mM),
Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
