Description
| Description | Qingyangshengenin B is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic and anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in C. elegans models of Alzheimer’s disease. Otophylloside B can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish. |
| In vitro | Otophylloside B (Ot B)?could modestly extend the lifespan of C. elegans, delay the age-related decline of body movement and improve the stress resistance.?Further investigating the molecular mechanism of lifespan extension effect revealed that Ot B could activate the FOXO transcription factor DAF-16.?Ot B could not further extend the lifespan of long-lived mutant of insulin/IGF-1-like receptor (daf-2).?In addition, Ot B also requires SIR-2.1 and CLK-1 which is an enzyme in ubiquinone synthesis, for lifespan extension. |
| Source |
| Synonyms | Otophylloside B |
| Molecular Weight |
923.13 |
| Formula | C49H78O16 |
| CAS No. | 106758-54-7 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: <9.23mg（10.00mM）
( < 1 mg/ml refers to the product slightly soluble or insoluble )
