Description
| Description | Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action. |
| Targets&IC50 | murine LPA2 subtype:（EC50）25 nM |
| In vitro | In MEF and IEC-6 cells expressing LPA2, Radioprotectin-1 (0, 0.1, 0.3, 1.0, and 3 μM) effectively reduces apoptosis induced by gamma-irradiation and the radiomimetic chemotherapeutic Adriamycin[1]. |
| In vivo | In C57BL/6 female mice, Radioprotectin-1 (0.1 and 0.3 mg/kg; s.c.) decreases the mortality in models of the hematopoietic and gastrointestinal acute radiation syndrome[1]. |
| Molecular Weight |
486.92 |
| Formula | C23H19ClN2O6S |
| CAS No. | 1622006-09-0 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 100 mg/mL (205.4 mM),
Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
