Description
| Description | (S)-3,4-DCPG HCl ((S)-3,4-Dicarboxyphenylglycine HCl) is a selective metabotropic glutamate receptor 8a (mGluR8a) agonist that has an effect on human mGluR8-expressing AV12-664 cells with an EC50 of 31 nM. |
| Targets&IC50 | mGluR8a (human):31 nM (EC50) |
| In vivo | (S)-3,4-DCPG (3-100 mg/kg, i.p.) maked c-Fos as an indicator of neuronal activity in specific brain regions 2 hours after systemic administration. In wild-type mice, (S)-3,4-DCPG (100 mg/kg) significantly increased c-Fos expression in several stress-related brain regions: paraventricular nucleus of the hypothalamus, central nucleus of the amygdala, lateral parabrachial nucleus and locus coeruleus.[2] |
| Synonyms | (S)-3,4-Dicarboxyphenylglycine HCl, (S)-3,4-DCPG HCl(201730-11-2 Free base) |
| Molecular Weight |
275.64 |
| Formula | C10H10ClNO6 |
| CAS No. | T23288L |
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 10 mg/mL (36.28 mM)
