Description
| Description | Urocortin (Ucn) is a 40 amino acid peptide which is closely related to corticotrophin-releasing factor (CRF). |
| Targets&IC50 | mCRF2β: 0.5 nM, hCRF1:0.4nM, rCRF2α:0.3 nM |
| In vitro | Urocortin, human is a selective agonist of CRF2?receptor, with Kis of 0.4, 0.3, and 0.5 nM for human CRF1, rat CRF2α?and mouse CRF2β?receptors in cell assay, respectively[1]. |
| In vivo | Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. It appears to be a more potent suppressor of ingestive behavior. Urocortin has the potential of inducing anxiogenic behavior[2]. |
| Synonyms | Human urocortin I, Human urocortin, Human urocortin 1, Urocortin (human) |
| Molecular Weight |
4696.32 |
| Formula | C204H337N63O64 |
| CAS No. | 176591-49-4 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
( < 1 mg/ml refers to the product slightly soluble or insoluble )
