What causes some pregnancies to result in Preeclampsia?
Since the early 1990’s, there has been an explosion of research and discovery around the problem of preeclampsia and the correlated growth factor, VEGF. Preeclampsia has been a menace of pregnancies for ages and still affects anywhere from 2-10% of pregnancies...
Amphotericin B – the Anti-Resistant Antifungal
Antibiotic resistance is certainly more of a rule than a question and one which I have discussed several times. The relatively simple genetic structure of bacterial and fungal pathogens and their fast population turnover rate make resistance mutations both likely and...
Abiotic Stress On Auxin Levels – What’s Cold Got To Do With It?
The growth and development of plants are governed by the induction, suppression or transmission of phytohormones such as Indole-3-acetic acid (IAA), sometimes known as auxin. The sessile nature of plants demands some kind of chemical response to all manners of...
Historical Necessity of Tryptophan and TB?
In the US, we are once again preparing for that glorious day of turkey, Thanksgiving. The stuffing is being prepared, the cranberry sauce just as Grandma would have wanted it, the pies are getting baked…and the search engines are alight with thousands (if not...
The Inhibition of a Chordoma Xenograft
In the universe of cancers, there are an overabundance of different types. Not just in terms of where a particular cancer tends to show up (such as ovarian cancers, prostate cancer, etc.), but in how the cancer grows or spreads. In fact, apart from the obvious broader...
Attention! Calling for Bacterial Cells to Line up Single File for Analysis!
Sometimes, the smallest of things have the biggest impact on our lives. Bacteria inundate every crevice of every larger crevice of our existence. They sustain us, enrich us, immunize us, and sometimes, they kill us. It’s really hard to consider yourself a...
Rudolph had a very shiny nose?
One of my favorite holiday traditions as a child was watching the amazingly adorable (and horrible claymation) Christmas special, “Rudolph the Red-nosed Reindeer” which always aired every December on one of the three prime-time networks (this was way back in the dark...
How can you label coral symbiotic protein interactions? With Biotin, of course!
Corals are fascinating and beautiful creatures. It’s also a fairly safe bet that most everyone would agree with that statement, judging from the millions of tourists and visitors to our world’s most famous coral reefs every year, and the billions in generated revenue...
There’s Gold on those DNA Molecules!
As I continue to search for novel and interesting applications for the interaction between biotin and streptavidin, I love seeing the variety of applications that scientists from around the world dream up and develop! Most recently, I came across a paper describing a...
Improving Fluorescence Detection… with Mirrors
luorescent labeling is one of the most versatile tools that science has engineered over the last century. From DNA probes to protein labeling to immunoassays (like ELISAs) to microarray chips, fluorescent labeling has allowed us to see or detect the innermost workings...
Detecting Osteosarcoma (OSA) in dogs with Surface Protein Biotinylation
pparently, I am a dog person. It might actually be truer to say that I like all animals, but I’m sure that if you were able to ask my dog her opinion, she would tell you: I am a dog person. As a product of my culture, I spend an inordinate amount of money and time on...
Prospecting for Proteins of a Parasitic Protozoan
n the comfortable culture of the U.S., which we take for granted all too often, it can be difficult to remember the human plagues and diseases that have followed mankind throughout the millennia. It’s difficult to remember that we, ourselves, are the preferred...
Improving Vaccine Efficacy with EDAvidin (EDA-Streptavidin)
I believe that our current quality of life has been most affected by the discovery of vaccines, even more so than by our use of antibiotics. I also firmly believe that the benefits of those vaccines outweigh any and all side-effects, disadvantages and the...
A Better Way to Detect the Onset of Diabetes
t is probably a safe bet that everyone reading this knows at least one person who has diabetes. Diabetes is such a common disease in our culture, we hardly blink anymore when we find out that someone has it, as opposed to more ominous diseases like cancer,...
Decoding the Circadian Clock
There is, I think, one thing that unifies nearly every species on Earth, a single constant that goes beyond similarities in DNA, genomes, cells or evolution. A “universal” tie-in which, even if you could genetically engineer and build from scratch an entirely new...
GoldBio’s Bialaphos is Used to Raise the Bar (Gene) Even Higher
Farmers are constantly in need of a more diversified herbicide treatment program. Though RoundUp has held the position of the world’s top selling herbicide for quite some time, scientists and farmers have been hard at work testing alternatives, such as bialaphos, to...
A New Frontier for DNA: The Molecule, Now Made Machine
Lifesaving, man-made “nano-bots,” something long imagined in fiction, are now being brought to life through DNA origami. What started out as a nanoscale 3-D box sculpted from DNA, and later, 2-D renderings of DNA-drawn world maps, smiley faces, snowflakes and...
Catching GoldBio’s Bialaphos and PPT ‘in the Rye’grass Transformation Protocol of Tomorrow
In part two of our series of blogs highlighting recently published research involving the use of bialaphos and PPT, we now present a summary of exciting research utilizing Gold Biotechnology’s bialaphos and phosphinothricin (PPT) to demonstrate dramatically improved...
In Sickness and in Health: Our Symbiotic Marriage
Our modern day view of our bodies has changed quite drastically over the last century. With increased medical knowledge and the ability to detect ever-smaller and rarer life, we have continuously advanced our awareness of the world beyond that which even science...
Your Hypothesis May Soon be Elementary, Thanks to Watson
When I was a young research associate, having just recently started down a career of molecular biology and facing the insurmountable task of figuring out what to work on, I received some of the best research advice from an equally young and unequivocally wise...
Don’t Fear the Reaper: Live Long and Prosper with NAD+
Whether we are conscious of it or not, we will spend our entire life trying to elude death. Despite fruitless attempts to escape, our healthy instincts never allow us to put down the quest. Our heavily programmed will to live goes beyond fight or flight; it has...
An Infamous Poison Makes a Hopeful Cure
Sir, if you were my husband, I’d put arsenic in your tea.” -Lady Astor to Winston Churchill Being colorless, odorless, tasteless in food and beverages, and appearing to cause symptoms similar to food poisoning, arsenic has had a sinister history as an ideal poison....
Old Antibiotics Won’t Spoil Research with this Test
You hold up a bottle of old antibiotic stock solution and wonder if it's still good? Learn how to quickly determine whether your old antibiotic solutions are still good to use. It happens to us all on occasion – an urgent craving attacks, and it must be addressed...
Bursting the Bubble, Slaying the `Rat King’
So, you’ve tricked your favorite E. coli expression strain into making gobs of your protein of interest (POI). The SDS-PAGE gel shows a whopping excess of what you have decided to nickname ‘OCD-Linked Zelda Legendase’. Great! This is always an encouraging result, but...