[KO Validated] APP Rabbit mAb

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

• Research Area & PathwaysEpigenetics & Nuclear SignalingTranscription Factors
• Research Area & PathwaysProtein phosphorylation
• Research Area & PathwaysImmunology & InflammationJak-Stat-IL-6 Receptor Signaling Pathway
• Research Area & PathwaysNeuroscienceNeurodegenerative DiseasesAmyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer’s Disease
• Research Area & PathwaysNeuroscienceNeurodegenerative DiseasesNeurodegenerative Diseases Markers