[KO Validated] STAT3 Rabbit mAb

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome.

• Research Area & PathwaysEpigenetics & Nuclear SignalingTranscription Factors
• Research Area & PathwaysProtein phosphorylation
• Research Area & PathwaysSignal TransductionErbB-HER Signaling Pathway
• Research Area & PathwaysSignal TransductionMAPK-Erk Signaling Pathway
• Research Area & PathwaysSignal TransductionMAPK-JNK Signaling Pathway
• Research Area & PathwaysCell Biology & Developmental BiologyApoptosisInhibition of Apoptosis
• Research Area & PathwaysCell Biology & Developmental BiologyCytoskeletonMicrotubules
• Research Area & PathwaysImmunology & InflammationJak-Stat-IL-6 Receptor Signaling Pathway
• Research Area & PathwaysStem CellsEmbryonic Stem Cells
• Research Area & PathwaysCardiovascularHeartCardiogenesis
• Research Area & PathwaysCardiovascularHeartHypertrophy
• ProductsRecombinant ProteinsDrug Targets