Description
Overview
Product name |
TYROBP Rabbit pAb |
Catalog No. |
A5385 |
Host species |
Rabbit |
Purification method |
Affinity purification |
Isotype |
IgG |
Background
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.
Immunogen information
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human TYROBP (NP_003323.1). |
Sequence |
MGGLEPCSRLLLLPLLLAVSGLRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK |
Gene ID |
|
Swiss Prot |
|
Synonyms |
DAP12; KARAP; PLOSL; PLOSL1 |
Calculated MW |
12kDa |
Observed MW |
|
Applications
Research Area
* For research use only. Not for therapeutic or diagnostic purposes.